Background:

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

Applications:

WB

Name of antibody:

MBP

Immunogen:

Synthetic peptide of human MBP

Full name:

myelin basic protein

Synonyms：

MGC99675

SwissProt:

P02686

WB Predicted band size:

33 kDa

WB Positive control:

Rat brain, Mouse brain and Rat hippocampus Tissue

WB Recommended dilution:

500-1000